YooForic CBD Gum Forty-three healthy volunteers received 15 mg of oral THC, and the metabolites of THC and 11-OH-THC and THC-COOH were measured over time and eventually reported their subjective response. It turns out that for every 'C allele' that someone carries in their body, the CYP2C9 enzyme becomes less active when THC is 'broken down'. In other words, CC carriers had an average of 3 times the amount of THC in their system than AA carriers. AC carriers had as much as 2 times more THC than AA carriers. Consequently, because THC is converted, as indicated by the enzyme into THC-COOH Para, DC carriers were on average with 15% of this inactive metabolite in their system, compared to AA carriers. This can be seen quite clearly at the far right of the first diagram above. Now it gets really interesting, the THC COOH metabolite is the one that is sought in urine tests to find traces of marijuana and to help determine if someone has recently smoked cannabis. Soon we will come to that. The CC carriers reported the same study a longer effect after THC consumption, as shown in the graph below. Participants in the study reported their subjective experience for 3 days and, as you can see, CC vehicles showed a significant increase in THC after 72 hours. Since this study was conducted by oral cannabis absorption, it is important to remember and take note of the differences between smoking cannabis and eating it. When eating THC, the process of decomposing THC begins in the intestine, so CYPC29 begins to do its job earlier when smoked, CYP2C9 has less influence on the intensity of the "high", but the same duration. There is much more to explore in this area, for example, different methods of smoking in combination with CYP2C9 or in combination with other genes. The list continues, hoping that a more relaxed research climate around cannabis for the next few years will produce interesting and useful studies. CYP2C9 and drug testing Contrary to popular belief, THC has not remained in its system for a long time.